859027-20-6 Usage
Chemical structure
A complex molecule containing a piperazine ring with an ethyl group and a nitro group attached, as well as a trifluoromethyl substituted benzyl group.
Pharmaceutical research
Used in the development of new drugs due to its potential therapeutic properties.
Health risks
Should be handled with caution as it may pose health risks if not used properly.
Medicinal chemistry
Represents an interesting molecular scaffold for studies due to its unique structure and potential pharmacological activities.
Nitro group
A functional group containing a nitrogen atom bonded to two oxygen atoms, which can be involved in various chemical reactions and may contribute to the compound's pharmacological properties.
Trifluoromethyl group
A functional group containing a carbon atom bonded to three fluorine atoms, which can influence the compound's lipophilicity, reactivity, and biological activity.
Benzyl group
A phenylmethyl group derived from benzene, which can be involved in various chemical reactions and may contribute to the compound's stability and biological activity.
Ethyl group
A small alkyl group derived from ethane, which can influence the compound's lipophilicity and steric properties.
Piperazine ring
A six-membered heterocyclic ring containing two nitrogen atoms, which is a common structural motif in many pharmaceuticals and can be involved in various biological activities.
Drug development
The compound's potential therapeutic properties make it a candidate for further research and development as a new drug.
Check Digit Verification of cas no
The CAS Registry Mumber 859027-20-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,9,0,2 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 859027-20:
(8*8)+(7*5)+(6*9)+(5*0)+(4*2)+(3*7)+(2*2)+(1*0)=186
186 % 10 = 6
So 859027-20-6 is a valid CAS Registry Number.
859027-20-6Relevant articles and documents
Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties
Lee, Jung Wuk,Park, Jiwon,Kim, Jina,Kim, Jihyung,Choi, Changyu,Min, Kyung Hoon
, (2021/03/14)
Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1
Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity
El-Damasy, Ashraf Kareem,Cho, Nam-Chul,Nam, Ghilsoo,Pae, Ae Nim,Keum, Gyochang
supporting information, p. 1587 - 1595 (2016/08/28)
Herein we report the discovery of compound 6 [KST016366; 4-((2-(3-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)benzo[d]thiazol-6-yl)oxy)picolinamide] as a new potent multikinase inhibitor through minor structural modification of our
ISOQUINOLINE-5-CARBOXAMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE
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Paragraph 0188-0190, (2015/07/15)
A compound selected from the group consisting of an isoquinoline-5-carboxamide derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate and a solvate thereof is effective for the prevention or treatment of diseases associated with abnormal cell growth, which are caused by abnormal activation of a protein kinases.
