859027-30-8

Basic information

• Product Name: 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline
• Synonyms: 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline
• CAS NO: 859027-30-8
• Molecular Formula: C₁₇H₂₄F₃N₃O₂
• Molecular Weight: 359.39
• Mol File: 859027-30-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 412.422°C at 760 mmHg
• Flash Point: 203.226°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• PKA: 5.99±0.10(Predicted)
• CAS DataBase Reference: 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline(859027-30-8)
• EPA Substance Registry System: 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline(859027-30-8)

Safety Data

• Hazardous Substances Data: 859027-30-8(Hazardous Substances Data)

Usage

Description

4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline is a chemical compound that belongs to the class of aniline derivatives. It has a molecular formula C16H20F3N3O2 and a molecular weight of 345.34 g/mol. 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline is a derivative of aniline with a trifluoromethyl group and a Boc-protected piperazine moiety, making it a valuable intermediate for the synthesis of various bioactive molecules.

Uses

Used in Pharmaceutical Industry:
4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline is used as a building block in organic synthesis and medicinal chemistry for the development of pharmaceuticals. Its Boc-protected piperazine group can be easily removed under mild conditions, allowing for the synthesis of various bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline serves as a valuable intermediate for the synthesis of agrochemicals. Its unique structure and functional groups contribute to the development of new compounds with potential applications in agriculture, such as pesticides or herbicides.

InChI:InChI=1/C17H24F3N3O2/c1-16(2,3)25-15(24)23-8-6-22(7-9-23)11-12-4-5-14(21)13(10-12)17(18,19)20/h4-5,10H,6-9,11,21H2,1-3H3

Upstream product

• 50551-17-2 4-nitro-2-(trifluoromethyl)benzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 694499-22-4 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 
• 859027-32-0 4-(4-nitro-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 943320-72-7 C₂₅H₂₉F₃IN₃O₃ 
• 1232836-37-1 3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide 
• 1613169-09-7 tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate 
• 1613168-69-6 N-(5-(4-((2-oxo-2-((4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)amino)ethyl)amino)phenyl)pyridin-2-yl)cyclopropanecarboxamide 
• 1613168-67-4 2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide 
• 1613168-37-8 N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)-2-(4-(pyridin-3-yl)phenoxy)acetamide 
• 1613169-18-8 tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate 

Relevant articles and documents

ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES

The present invention discloses compounds according to Formula (I) wherein R1, R2, R3, L1, L2, and L3 are as defined herein. The present invention relates to compounds inhibiting discoidin domain receptors (DDRs), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering a compound of the invention.

DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

The present application provides bifunctional compounds of Formula (I), or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for protein kinases (e.g., Bcr-Abl). The present application also relates to methods for the targeted degradation of one or more protein kinases through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to one or more protein kinases which can be utilized in the treatment of disorders modulated by protein kinases.

BCR-ABL DIPLOID INHIBITOR, PREPARATION METHOD THEREFOR, AND USES THEREOF

Disclosed are compounds or pharmaceutically acceptable salts thereof having the following general formula: R-Linker-R. The compounds or pharmaceutically acceptable salts thereof provided by the present invention are used as Bcr-Abl diploid inhibitors, whi