859055-95-1 Usage
Type of compound
Ketone
Pyridine ring
A six-membered aromatic ring with one nitrogen atom
Methyl group
A single carbon atom (-CH3) attached to the pyridine ring
Propanone side chain
A three-carbon chain with a carbonyl group (C=O) at the end
Chemical reactions
Used in various chemical reactions and organic synthesis processes
Pharmaceutical industry
Building block for the synthesis of biologically active compounds
Intermediate
Valuable intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals
Flavor and fragrance industry
Used in the creation of flavors and fragrances
Physical properties
Not provided in the material, but typically, ketones have low melting points and are often liquid at room temperature
Solubility
Not provided in the material, but ketones are generally soluble in organic solvents like ethanol, methanol, and acetone
Reactivity
Not provided in the material, but ketones are known to participate in various reactions such as nucleophilic addition, oxidation, and reduction
Safety and handling
Not provided in the material, but it is important to follow proper safety protocols when handling chemicals, including wearing appropriate personal protective equipment (PPE) and using proper ventilation.
Check Digit Verification of cas no
The CAS Registry Mumber 859055-95-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,9,0,5 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 859055-95:
(8*8)+(7*5)+(6*9)+(5*0)+(4*5)+(3*5)+(2*9)+(1*5)=211
211 % 10 = 1
So 859055-95-1 is a valid CAS Registry Number.
859055-95-1Relevant articles and documents
Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones
Ochiai, Koji,Takita, Satoshi,Kojima, Akihiko,Eiraku, Tomohiko,Ando, Naoki,Iwase, Kazuhiko,Kishi, Tetsuya,Ohinata, Akira,Yageta, Yuichi,Yasue, Tokutaro,Adams, David R.,Kohno, Yasushi
supporting information, p. 5833 - 5838 (2012/11/07)
(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4, 5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. Here we show that a 4,4-dimethylpyrazolone subunit serves as an effective surrogate for the 5-methyl-4,5-dihydropyridazin-3(2H)-one ring of KCA-1490 whilst lacking a stereogenic centre. The 2- and 7-substituents in the pyrazolo[1,5-a]pyridine subunit markedly influence the PDE-inhibitory profile and can be adjusted to afford either potent PDE4-selective inhibitors or dual PDE3/4 inhibitors. A survey of bicyclic heteroaromatic replacements for the pyrazolo[1,5-a]pyridine allowed further refinement of the inhibitory profile and identified 3-(8-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-5-yl)-4, 4-dimethyl-1H-pyrazol-5(4H)-one as an orally active, achiral KCA-1490 analog with well-balanced dual PDE3/4-inhibitory activity.
