859085-75-9

Basic information

• Product Name: 5,7-dihydroxy-3-(3,4,5-trimethoxybenzoyl)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
• Synonyms: 5,7-dihydroxy-3-(3,4,5-trimethoxybenzoyl)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
• CAS NO: 859085-75-9
• Molecular Weight: 538.508
• Mol File: 859085-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-dihydroxy-3-(3,4,5-trimethoxybenzoyl)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-3-(3,4,5-trimethoxybenzoyl)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(859085-75-9)
• EPA Substance Registry System: 5,7-dihydroxy-3-(3,4,5-trimethoxybenzoyl)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(859085-75-9)

Safety Data

• Hazardous Substances Data: 859085-75-9(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 1719-88-6 3,4,5-trimethoxybenzoic anhydride 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 18103-42-9 5,7-dihydroxy-3',4',5'-trimethoxyflavone 

Relevant articles and documents

A concise synthesis of (±)-7-O-galloyltricetiflavan

(±)-7-O-galloyltricetiflavan (1a) was synthesized successfully in five steps from the commercially available trihydroxyacetophenone (2) and trimethoxybenzoyl chloride (3). The flavone 4a was prepared in a one-pot reaction and it gave hex-O-methylflavan 6 followed by acylation and reduction. However, the demethylation of flavan 6, 5-O-acetylflavan 10 and 5-O-phenylacetylflavan 11 by BBr3 gave all the hydrolyzed fragments 7 and 8 as the major products. By contrast, in the same condition, hept-O-methylflavan 9 could provide the desired product (±)-7-O-galloyltricetiflavan (1a) in 91% yield. The additional 5-O-B-Br2 complex may stabilize the ester bond during the demethylation process.