85929-96-0

Basic information

• Product Name: 2-tert-Butylpyrimidin-5-ol
• Synonyms: 5-pyrimidinol, 2-(1,1-dimethylethyl)-; 2-(1,1-dimethylethyl)-5-pyrimidinol
• CAS NO: 85929-96-0
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.1937
• Mol File: 85929-96-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 236.6°C at 760 mmHg
• Flash Point: 96.9°C
• Density: 1.079g/cm³
• Vapor Pressure: 0.0306mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2-tert-Butylpyrimidin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butylpyrimidin-5-ol(85929-96-0)
• EPA Substance Registry System: 2-tert-Butylpyrimidin-5-ol(85929-96-0)

Safety Data

• Hazardous Substances Data: 85929-96-0(Hazardous Substances Data)

Usage

General Description

2-tert-Butylpyrimidin-5-ol, also known as TBP, is a chemical compound with the molecular formula C9H14N2O. It is a pyrimidine derivative and a metabolite of thiamine (vitamin B1). TBP has been identified as a potential anti-inflammatory and antioxidant compound, and it has shown potential in the treatment of neurological disorders and neurodegenerative diseases. It is also being studied for its potential use in the development of new drugs for the treatment of conditions such as Alzheimer's disease. TBP is a promising compound with potential applications in both the pharmaceutical and nutraceutical industries.

Upstream product

• 91167-21-4 5-chloro-2-(1,1-dimethylethyl)pyrimidine 
• 85929-94-8 5-Bromo-2-(1,1-dimethylethyl)pyrimidine 
• 124053-04-9 3,4,5,6-tetrahydro-2-tert-butyl-5-hydroxypyrimidine 
• 75-98-9 Trimethylacetic acid 
• 61319-99-1 2-tert-butylpyrimidine 
• 67-56-1 methanol 
• 865-47-4 potassium tert-butylate 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 1051372-51-0 2-tert-butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)pyrimidine 

Relevant articles and documents

A New Preparation of 5-Hydroxypyrimidines Derived from Carboxylic Acids, Epichlorohydrin, and Ammonia

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Preparation of phosphoric acid derivatives and intermediates

A process for the preparation of a compound of the formula STR1 in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl, R1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl, R2 is optionally substituted alkyl, and Y is oxygen or sulphur, comprising (a1) reacting a compound of the formula STR2 with STR3 or with in which R5 is R except for hydrogen, or equivalent, to produce STR4 oxidizing that compound or its salt to STR5 and phosphorylating. Several of the intermediates are new.

Process for the preparation of phosphoric acid derivatives and intermediate products

The process which comprises STR1 in which R represents hydrogen, alkoxy, alkylamino or dialkylamino or represents optionally substituted radicals from the series comprising alkyl, cycloalkyl and aryl, R1 represents optionally substituted radicals from the series comprising alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl, R2 represents optionally substituted alkyl, R3 represents alkyl, alkoxy or aryl, X represents oxygen or sulphur, and Y represents halogen or a grouping --OCOR3. The intermediates do not have to be isolated. Some are new compounds.