859833-21-9Relevant articles and documents
Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling
Aizawa, Yoko,Ashikari, Yosuke,Colella, Marco,Fujita, Chiemi,Higuma, Ryosuke,Ishikawa, Susumu,Jiang, Yiyuan,Luisi, Renzo,Maekawa, Kei,Nagaki, Aiichiro,Sakaue, Hodaka,Shimizu, Yutaka,Shite, Ibuki,Takahashi, Yusuke,Takegawa, Toshihiro,Takumi, Masahiro,Yamashita, Hiroki,Yonekura, Yuya
, p. 618 - 622 (2020/02/04)
In a flow microreactor, aryllithiums bearing a piperidylmethyl group were generated using nBuLi by precise residence time control and effective temperature control, and then selectively borylated with boronic esters such as 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (BpinOiPr) and trimethyl borate B(OMe)3 by fast mixing. Moreover, the direct integration with Suzuki–Miyaura cross coupling were successfully achieved to obtain nitrogen-containing biaryl compounds. The present method could be applied for the straightforward synthesis of the key intermediate of a bioactive component bearing a piperidylmethyl-biphenyl framework.
ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS
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Page/Page column 41-42, (2015/06/25)
The present invention is directed to acylguanidines which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPHl), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
Synthesis of amines with pendant boronic esters by borrowing hydrogen catalysis
Ma, Winson M. J.,James, Tony D.,Williams, Jonathan M. J.
, p. 4850 - 4853 (2013/10/08)
Amine alkylation reactions of alcohols have been performed in the presence of boronic ester groups to provide products which are known to have use as molecular sensors. The boronic ester moiety could be present in either the alcohol or amine starting mate