85989-62-4

Basic information

• Product Name: Carbamic acid, methoxy-, phenyl ester
• Synonyms: methoxy-carbamic acid phenyl ester;Carbamic acid,methoxy-,phenyl ester
• CAS NO: 85989-62-4
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Mol File: 85989-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, methoxy-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, methoxy-, phenyl ester(85989-62-4)
• EPA Substance Registry System: Carbamic acid, methoxy-, phenyl ester(85989-62-4)

Safety Data

• Hazardous Substances Data: 85989-62-4(Hazardous Substances Data)

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 1885-14-9 phenyl chloroformate 
• 67-62-9 O-Methylhydroxylamin 

Downstream Products

• 67-62-9 O-Methylhydroxylamin 
• 108-95-2 phenol 
• 918144-33-9 {(R)-3-[4-(1-cyclohexylmethyl-3-methoxy-ureido)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Catalytic substitution/cyclization sequences of: O -substituted Isocyanates: Synthesis of 1-alkoxybenzimidazolones and 1-alkoxy-3,4-dihydroquinazolin-2(1 H)-ones

O-Substituted isocyanates (O-isocyanates) have rarely been used in organic synthesis, given their tendency to undergo side reactions (e.g., trimerization). Herein, we show that masked (blocked) O-isocyanate precursors allow one-pot or cascade reaction sequences featuring base-catalyzed substitution with 2-iodoanilines and 2-iodobenzylamines followed by copper-catalyzed cyclization, to form benzimidazolones and 3,4-dihydroquinazolin-2(1H)-ones. This work shows that O-isocyanates can serve as efficient building blocks for the synthesis of hydroxylamine-containing heterocycles.