859964-70-8

Basic information

• Product Name: 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine
• Synonyms: 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine
• CAS NO: 859964-70-8
• Molecular Weight: 292.381
• Mol File: 859964-70-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine(859964-70-8)
• EPA Substance Registry System: 4-cyano-1-(4-methoxyphenyl)-4-phenylpiperidine(859964-70-8)

Safety Data

• Hazardous Substances Data: 859964-70-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 
• 1448-52-8 N,N-bis(2-chloroethyl)-4-methoxybenzenamine 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 859964-86-6 1-(4-hydroxy-phenyl)-4-phenyl-piperidine-4-carboxylic acid 

Relevant articles and documents

A 4-substituted piperidine derivatives synthetic method

The invention relates to a synthesis method of 4-substituted piperidine derivatives. The synthesis method comprises the following steps: continuously reacting alpha-single substituted acetonitrile serving as a raw material with two-molecular ethylene oxide in the presence of a base I, thereby synthesizing compounds (2), wherein not one compound (2) is generated, and the compounds (2) are in tautomeric equilibrium with a compound (6); breaking the balance in the presence of a base II to generate an alcoxyl negative ion compound (3); reacting the compound (3) with R2SO2X or (R2SO2)2O to generate sulphonates (4); performing a cyclization reaction on the sulphonates (4) and primary amine to synthesize 4-substituted piperidine derivatives. Compared with a document reported method, the synthesis method has the advantages that the reaction steps are shortened and the synthetic efficiency is improved.