85999-41-3Relevant articles and documents
Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase
Liu, Jie,Zhang, Hengyuan,Zhu, Peiqing,Wu, Xiaoming,Yao, Hequan,Ye, Wencai,Jiang, Jieyun,Xu, Jinyi
, p. 50 - 55 (2015)
Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs.
Synthesis and biological activity of 23-hydroxybetulinic acid c-28 ester derivatives as antitumor agent candidates
Bi, Yi,Xu, Jinyi,Sun, Fei,Wu, Xiaoming,Ye, Wencai,Sun, Yijun,Huang, Wenwen
, p. 8832 - 8841 (2012/11/13)
23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC50 values of 8.35 μM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase
Zhu, Peiqing,Bi, Yi,Xu, Jinyi,Li, Zan,Liu, Jun,Zhang, Luyong,Ye, Wencai,Wu, Xiaoming
body text, p. 6966 - 6969 (2010/06/19)
A series of 23-hydroxybetulinic acid derivatives were prepared and tested in vitro as a new class of inhibitors of glycogen phosphorylase (GP). Within this series of compounds, 12b (IC50 = 3.5 μM) is the most potent GPa inhibitor. The preliminary SAR results of the 23-hydroxybetulinic acid derivatives are discussed.
