860031-89-6

Basic information

• Product Name: 5-(4-chloro-benzoyl)-3-(3-chloro-benzyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one
• CAS NO: 860031-89-6
• Molecular Weight: 411.287
• Mol File: 860031-89-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-chloro-benzoyl)-3-(3-chloro-benzyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chloro-benzoyl)-3-(3-chloro-benzyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one(860031-89-6)
• EPA Substance Registry System: 5-(4-chloro-benzoyl)-3-(3-chloro-benzyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one(860031-89-6)

Safety Data

• Hazardous Substances Data: 860031-89-6(Hazardous Substances Data)

Upstream product

• 860031-86-3 1-(3-chloro-benzyl)-3-methyl-1,3-dihydro-benzoimidazol-2-one 
• 122-01-0 4-chloro-benzoyl chloride 
• 1849-01-0 1-methyl-2-benzimidazolone 
• 612-28-2 2-nitro-N-methylaniline 
• 4760-34-3 N-methyl-1,2-phenylenediamine 

Relevant articles and documents

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: Synthesis and activity

A series of analogs of tipifarnib (1) has been synthesized as inhibitors of FTase by substituting the benzimidazolones and indoles for the 2-quinolone of tipifarnib. The novel benzimidazolones are potent and selective FTase inhibitors (FTIs) with IC50 values of the best compounds close to that of tipifarnib. The current series demonstrate good cellular activity as measured in their inhibiting the Ras processing in NIH-3T3 cells, with compounds 2c and 2f displaying EC50 values of 18 and 22 nM, respectively.