86030-08-2

Basic information

• Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
• Synonyms: LABOTEST-BB LT01147747;4-CHLORO-2-NITRODIPHENYL SULFONE;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE;4-chloro-2-nitro-1-(phenylsulphonyl)benzene;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-Chloro-2-nitrodiphenyl sulphone;BTB-1
• CAS NO: 86030-08-2
• Molecular Formula: C₁₂H₈ClNO₄S
• Molecular Weight: 297.71
• Mol File: 86030-08-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 471.2°Cat760mmHg
• Flash Point: 238.8°C
• Appearance: /
• Density: 1.476g/cm³
• Vapor Pressure: 1.35E-08mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in DMSO (30 mg/ml)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• CAS DataBase Reference: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE(86030-08-2)
• EPA Substance Registry System: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE(86030-08-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 86030-08-2(Hazardous Substances Data)

Usage

Description

BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5

Uses

BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.

References

Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072 Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554 Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539 Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41 Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463

InChI:InChI=1/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H

Upstream product

• 4548-56-5 4-chloro-2-nitrophenyl phenyl sulfide 
• 4601-79-0 4-chloro-2-(hydroxyamino)phenyl phenyl sulphone 
• 108-98-5 thiophenol 
• 89-61-2 2,5-dichloronitrobenzene 

Downstream Products

• 31041-00-6 2-benzenesulfonyl-5-chloro-aniline 
• 4601-79-0 4-chloro-2-(hydroxyamino)phenyl phenyl sulphone 
• 31520-18-0 2-hydroxy-5,5'-dichloro-2'-phenylsulphonylazoxybenzene 

Relevant articles and documents

BTB-1 A small molecule inhibitor of the mitotic motor protein kif18A

Turning the motor off: A malachite green based assay leads to the identification of BTB-1 (see picture), the first small-molecule inhibitor of the mitotic motor protein Kif18A. BTB-1 reversibly inhibits the ATPase activity of the recombinant motor domain