860460-70-4

Basic information

• Product Name: N-cyclohexyl-5-methyl-2-phenylimidazo[1,2-a]pyridine-3-amine
• Synonyms: N-cyclohexyl-5-methyl-2-phenylimidazo[1,2-a]pyridine-3-amine
• CAS NO: 860460-70-4
• Molecular Weight: 305.423
• Mol File: 860460-70-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: N-cyclohexyl-5-methyl-2-phenylimidazo[1,2-a]pyridine-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-5-methyl-2-phenylimidazo[1,2-a]pyridine-3-amine(860460-70-4)
• EPA Substance Registry System: N-cyclohexyl-5-methyl-2-phenylimidazo[1,2-a]pyridine-3-amine(860460-70-4)

Safety Data

• Hazardous Substances Data: 860460-70-4(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 1824-81-3 2-Amino-6-methylpyridine 
• 931-53-3 Cyclohexyl isocyanide 
• 100-52-7 benzaldehyde 

Downstream Products

• 724-92-5 N-cicloesil-α-ossofenilacetamide 
• 1824-81-3 2-Amino-6-methylpyridine 

Relevant articles and documents

Choline chloride/urea as a deep eutectic solvent/organocatalyst promoted three-component synthesis of 3-aminoimidazo-fused heterocycles via Groebke-Blackburn-Bienayme process

The catalytic activity of urea-, metal- and organic acid-based/choline chloride deep eutectic solvents/organocatalysts was investigated for the synthesis of 3-aminoimidazo-fused heterocycles via a one-pot domino reaction of an aldehyde, an isocyanide and 2-aminoheterocycles. The urea-based/choline chloride system exhibited significant catalytic activity for the reaction and could be reused in four consecutive reactions with no considerable loss in catalytic activity.

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

Visible-light-activated C-C and C-N bond formation in the synthesis of imidazo[1,2-: A] pyridines and imidazo[2,1- b] thiazoles under catalyst and solvent-free conditions

The formation of a 3-aminoimidazo-fused heterocyclic compound and its derivatives through a multicomponent one-pot reaction, activated by visible light, is reported. The noticeable feature of this protocol is the utilization of a universally available energy source to activate the reaction. The reported methodology is the first protocol that represents the implementation of visible light for this Ugi-type synthesis from 2-aminoheterocycles, aldehydes, and isocyanides as well as offers the advantages of improved selectivity, outstanding yields, solvent and catalyst-free conditions, environmental sustainability and convenient access to starting materials.