860787-37-7

Basic information

• Product Name: 1-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]PHENYL)SULFONYL)TETRAHYDRO-4(1H)-PYRIDINONE
• Synonyms: 1-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]PHENYL)SULFONYL)TETRAHYDRO-4(1H)-PYRIDINONE
• CAS NO: 860787-37-7
• Molecular Formula: C15H15ClN2O4S2
• Molecular Weight: 386.87
• Mol File: 860787-37-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]PHENYL)SULFONYL)TETRAHYDRO-4(1H)-PYRIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]PHENYL)SULFONYL)TETRAHYDRO-4(1H)-PYRIDINONE(860787-37-7)
• EPA Substance Registry System: 1-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]PHENYL)SULFONYL)TETRAHYDRO-4(1H)-PYRIDINONE(860787-37-7)

Safety Data

• Hazardous Substances Data: 860787-37-7(Hazardous Substances Data)

Usage

Description

1-(4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenylsulfonyl)tetrahydro-4(1H)-pyridinone, also known as TAK-242, is a chemical compound belonging to the class of pyridinones. It is a potent and selective inhibitor of Toll-like receptor 4 (TLR4) signaling, which is essential for the activation of the innate immune response. TAK-242 has been studied for its potential therapeutic applications in various diseases and conditions, including sepsis, inflammatory diseases, and other immune-mediated disorders. It has demonstrated promising anti-inflammatory and immunomodulatory effects in preclinical studies, making it a promising candidate for the development of novel treatments for TLR4-mediated diseases.

Uses

Used in Pharmaceutical Industry:
1-(4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenylsulfonyl)tetrahydro-4(1H)-pyridinone is used as a therapeutic agent for the treatment of sepsis, inflammatory diseases, and other immune-mediated disorders. Its application is based on its potent and selective inhibition of TLR4 signaling, which plays a crucial role in the activation of the innate immune response. By targeting TLR4, TAK-242 can potentially modulate the immune system and provide relief from the symptoms and complications associated with these conditions.
Used in Research and Development:
In the field of research and development, 1-(4-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenylsulfonyl)tetrahydro-4(1H)-pyridinone is used as a valuable tool for studying the role of TLR4 in various diseases and conditions. Its potent and selective inhibition of TLR4 signaling allows researchers to investigate the underlying mechanisms of immune activation and inflammation, which can lead to the discovery of new therapeutic targets and the development of novel treatments for TLR4-mediated diseases.
Used in Drug Delivery Systems:
Similar to gallotannin, TAK-242 can also benefit from novel drug delivery systems to enhance its applications and efficacy against immune-mediated disorders. Various organic and metallic nanoparticles can be employed as carriers for TAK-242 delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes. This can potentially lead to more effective treatments for patients suffering from sepsis, inflammatory diseases, and other TLR4-mediated conditions.