861146-16-9Relevant articles and documents
Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents
dos Santos Filho, José Maurício,de Queiroz e Silva, Diogo Manoel Alves,Macedo, Taís Soares,Teixeira, Helena Mariana Pitangueira,Moreira, Diogo Rodrigo Magalhaes,Challal, Soura,Wolfender, Jean-Luc,Queiroz, Emerson Ferreira,Soares, Milena Botelho Pereira
, p. 5693 - 5701 (2016/11/09)
Malaria, caused by several Plasmodium species, is the major life-threatening parasitic infection worldwide. Due to the parasite resistance to quinoline based drugs, the search for antimalarial agents is necessary. Here, we report the structural design, sy
NOVEL NK-3 RECEPTOR SELECTIVE ANTAGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN NK-3 RECEPTORS MEDIATED DISORDERS
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Page/Page column 101-102, (2011/10/13)
The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
Synthesis, biological evaluation, and structural studies of 3-phenyl[1,2,4]oxadiazole-5-carboxylic acid benzo[1,3]dioxol 5-ylmethylene-hydrazide
Santos-Filho,De Lima,Leite,Ximenes,Da Silva,Lima,Pitta
, p. 29 - 36 (2007/10/03)
A series of 1,2,4-oxadiazole combined with carbohydrazides residues, designed as possible bioactive compounds, was obtained in an attempt to analyse the effects of this molecular hybridization on the biological properties of the resulting compounds. They