861218-13-5Relevant articles and documents
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na +/H+ exchanger isoform-1 (NHE-1) inhibitors
Lee, Sunkyung,Lee, Hyunsuk,Kyu, Yang Yi,Byung, Ho Lee,Yoo, Sung-Eun,Lee, Kyunghee,Nam, Sook Cho
, p. 2998 - 3001 (2007/10/03)
A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.