861407-17-2Relevant articles and documents
A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde
Torii, Sigeru,Inokuchi, Tsutomu,Kubota, Minoru
, p. 400 - 402 (1986)
A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66percent yields), derivatives of biologically and medicinally important nicotinic acid, is explored.The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.