86162-89-2

Basic information

• Product Name: Propanedioic acid, (2,6-dinitrophenyl)-, dimethyl ester
• CAS NO: 86162-89-2
• Molecular Formula: C11H10N2O8
• Molecular Weight: 298.209
• Mol File: 86162-89-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (2,6-dinitrophenyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (2,6-dinitrophenyl)-, dimethyl ester(86162-89-2)
• EPA Substance Registry System: Propanedioic acid, (2,6-dinitrophenyl)-, dimethyl ester(86162-89-2)

Safety Data

• Hazardous Substances Data: 86162-89-2(Hazardous Substances Data)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 99-65-0 meta-dinitrobenzene 
• 868-26-8 dimethyl 2-bromomalonate 
• 606-21-3 1-chloro-2,6-dinitrobenzene 

Downstream Products

• 1341124-14-8 C₉H₁₂N₂O₂ 
• 1338064-97-3 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide 
• 1341124-13-7 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 1341124-12-6 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 1341124-11-5 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 848679-01-6 N-(2-oxo-2,3-dihydro-1H-indol-4-yl)-N'-[4-(trifluoromethyl)benzyl]urea 
• 86162-90-5 methyl (2,6-dinitrophenyl)acetate 
• 37777-63-2 (2,6-dinitro-phenyl)-acetic acid 
• 86162-98-3 3-(4-nitrophenyl)-4-(p-tolylsulfonyl)-2,2a,3,4-tetrahydro-1H-pyrrolo<4.3.2-cd>indol-2-one 
• 86162-97-2 4-Methyl-N-{2-oxo-3-[1-(3,4,5-trimethoxy-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indol-4-yl}-benzenesulfonamide 
• 86162-96-1 4-Methyl-N-{2-oxo-3-[1-(3,4,5-trimethoxy-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indol-4-yl}-benzamide 
• 86162-95-0 4-Methyl-N-{3-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl}-benzamide 
• 86162-93-8 4-toluenesulfonamidooxindole 
• 86162-92-7 4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one 

Relevant articles and documents

TRPV1 vanilloid receptor antagonists with a bicyclic portion

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS

The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.

Synthesis of 2-(2,6-dinitrophenyl)malonates, -acetates and acetonitrile by copper-mediated vicarious nucleophilic substitution

A regioselective, vicarious nucleophilic substitution of 1,3- dinitrobenzene with α-bromo- and iodocarbanions proceeds in the presence of copper(1) tert-butoxide and pyridine giving 2,6-dinitrophenylmalonates, 2,6- dinitrophenylacetates or 2,6-dinitrophenylacetonitrile as the only isomers from bromomalonate esters, bromoacetate esters, iodoacetate esters or iodoacetonitrile, respectively. Without copper(I) tert-butoxide, the 4- substituted isomer is the only product. We believe that the reaction proceeds via a σ-adduct of 1,3-dinitrobenzene and halocarbanion from which hydrogen and halogen are eliminated. This elimination is dependent upon the concentration of copper(I) tert-butoxide.