861648-80-8

Basic information

• Product Name: tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate
• Synonyms: tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate
• CAS NO: 861648-80-8
• Molecular Weight: 345.226
• Mol File: 861648-80-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate(861648-80-8)
• EPA Substance Registry System: tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate(861648-80-8)

Safety Data

• Hazardous Substances Data: 861648-80-8(Hazardous Substances Data)

Upstream product

• 66494-26-6 methyl 1-[[(tert-butoxy)carbonyl]amino]cyclopropane-1-carboxylate 
• 88950-64-5 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid 
• 626-43-7 3,5-Dichloroaniline 

Downstream Products

• 861648-81-9 tert-butyl [1-(3,5-dichlorophenylaminomethyl)cyclopropyl]carbamate 
• 861648-74-0 6-(3,5-dichlorophenyl)-4,6-diazaspiro[2.4]heptan-5-one 
• 861648-91-1 7-(3,5-dichlorophenyl)-4,7-diazaspiro[2.5]octane-5,6-dione 

Relevant articles and documents

Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities

Diamide insecticides, represented by chlorantraniliprole (CHL), were widely applied in the control of lepidopteran insects. In efforts to develop bioactive diamides with novel scaffolds, we design and synthesized a series of diamides containing central amino acids to conformationally simulate CHL. Bioassay results indicated that most compounds containing 1-aminocyclopropane-1-carboxylic acid exhibited excellent larvacidal potency against Mythimna separate and Plutella xylostella. After a systematic structure–activity relationship study, 1–23 was identified as a potential insecticidal candidate with LC50 values of 34.920 mg·L?1 against M. separate and 61.992 mg·L?1 on P. xylostella. Finally, molecular docking revealed the possible binding mode of 1–23 with the target protein, ryanodine receptors.