86170-45-8

Basic information

• Product Name: 3-Butenoic acid, phenylmethyl ester
• CAS NO: 86170-45-8
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 86170-45-8.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 3-Butenoic acid, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butenoic acid, phenylmethyl ester(86170-45-8)
• EPA Substance Registry System: 3-Butenoic acid, phenylmethyl ester(86170-45-8)

Safety Data

• Hazardous Substances Data: 86170-45-8(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 24850-33-7 allyltributylstanane 
• 100-44-7 benzyl chloride 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 54322-10-0 glutaric acid monobenzyl ester 
• 625-38-7 but-3-enoic acid 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 100-51-6 benzyl alcohol 
• 593-60-2 Vinyl bromide 
• 625-35-4 trans-chrotonyl chloride 
• 105623-17-4 (Z)-N-(2-methylpropylidene)benzylamine N-oxide 
• 187661-86-5 buta-2,3-dienoic acid benzyl ester 
• 109-99-9 tetrahydrofuran 
• 201230-82-2 carbon monoxide 

Downstream Products

• 852402-28-9 4-bromobut-2E-enoic acid benzyl ester 
• 71338-71-1 benzyl (E)-2-butenoate 
• 123131-71-5 Benzyl 2-(2,2-difluorocyclopropyl)acetate 
• 130985-38-5 3-(benzyloxycarbonyl)propyl di-tert-butyl phosphate 
• 110930-71-7 phenylmethyl 4-chloro-3-hydroxybutanoate 
• 586952-21-8 benzyl (3-p-toluenesulfonyl-1,3-oxazolidin-2-on-4-yl)acetate 
• 586952-09-2 benzyl (E)-4-hydroxy-2-butenoate 

Relevant articles and documents

ARYLAMIDES AND METHODS OF USE THEREOF

The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

Synthesis of 2-Fluoroacetoacetic Acid and 4-Fluoro-3-hydroxybutyric Acid

The butyric acid scaffold is the base structure of several human metabolites that serve diverse and prominent biochemical roles including as oxidative sources of cellular energy and as substrates for biosynthesis. Derivatization of metabolites through incorporation of fluorine often alters bioactivity and can facilitate detection and analysis by nuclear magnetic resonance or positron emission tomography depending upon the fluorine isotope employed. We describe the synthesis of two new fluorinated butyric acids (and three related esters) that are derivatives of the metabolites acetoacetic acid and 3-hydroxybutyric acid. 4-Fluoro-3-hydroxybutyric acid is prepared from epoxy ester precursors via ring opening by triethylamine trihydrofluoride. 2-Fluoroacetoacetic acid is prepared by electrophilic fluorination of an acid-labile β-keto ester. The gradual pH-dependent decarboxylation of 2-fluoroacetoacetic acid is investigated by 19 F NMR spectroscopy.