861881-13-2

Basic information

• Product Name: 3-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)aniline
• Synonyms: 3-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)aniline
• CAS NO: 861881-13-2
• Molecular Weight: 258.287
• Mol File: 861881-13-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)aniline(861881-13-2)
• EPA Substance Registry System: 3-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)aniline(861881-13-2)

Safety Data

• Hazardous Substances Data: 861881-13-2(Hazardous Substances Data)

Upstream product

• 1529769-51-4 tert-butyl 4-[3-amino-5- (trifluoromethyl)phenyl]-piperidine-1-carboxylate 
• 16853-85-3 lithium aluminium tetrahydride 
• 1365803-08-2 1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine 
• 1365803-07-1 4-(3-nitro-5-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine 
• 1365803-06-0 tert-butyl 4-[3-nitro-5-(trifluoromethyl)phenyl]- 1,2,3,6-tetrahydropyridine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 630125-49-4 1-bromo-3-nitro-5-(trifluoromethyl)benzene 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1135493-55-8 N-[3-(1-methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide 

Relevant articles and documents

NOVEL INHIBITORS OF MAP4K1

The invention relates to novel inhibitors of MAP4K1 (HPK1) useful for the treatment of diseases or disorders characterised by dysregulation of the signal transduction pathways associated with MAPK activation, including hyperproliferative diseases, diseases of immune system dysfunction, inflammatory disorders, neurological diseases, and cardiovascular diseases. The invention further relates to pharmaceutical compositions comprising the same and methods of treatment of said diseases and disorders. The inhibitors are of formula (I) wherein the definitions for A, D, E, F, R5, R6, R7, Z, ring Q, n, x and y are as given in the application.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.