861928-27-0

Basic information

• Product Name: 4-BROMO-2-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 4-BROMO-2-(TRIFLUOROMETHYL)BENZALDEHYDE;5-Bromo-2-formylbenzotrifluoride, 4-Bromo-alpha,alpha,alpha-trifluoro-o-tolualdehyde
• CAS NO: 861928-27-0
• Molecular Formula: C8H4BrF3O
• Molecular Weight: 253.0159696
• Mol File: 861928-27-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 48-50 ºC
• Boiling Point: 243 ºC
• Flash Point: 101 ºC
• Appearance: /
• Density: 1.677
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Refrigerated.
• Water Solubility: Sparingly soluble in water (0.083 g/L) (25°C).
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(861928-27-0)
• EPA Substance Registry System: 4-BROMO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(861928-27-0)

Safety Data

• Hazardous Substances Data: 861928-27-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Uses

4-Bromo-2-(trifluoromethyl)benzaldehyde is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a pharmaceutical intermediate and intermediate in organic syntheses.

InChI:InChI=1/C8H4BrF3O/c9-6-2-1-5(4-13)7(3-6)8(10,11)12/h1-4H

Upstream product

• 7657-09-2 1,4-dibromo-2-(trifluoromethyl)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 955946-11-9 4-bromo-1-(dibromomethyl)-2-(trifluoromethyl)benzene 
• 364-12-5 4-bromo-1-iodo-2-(trifluoromethyl)benzene 
• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 707-72-2 o-trifluoromethyl-α,α-dichlorotoluene 
• 2591-86-8 N-Formylpiperidine 

Downstream Products

• 1197231-94-9 1-(4-bromo-2-(trifluoromethyl)phenyl)ethan-1-one 

Relevant articles and documents

2-benzoyl malonate compound as well as preparation method and application thereof

The invention discloses a 2-benzoyl malonate compound as well as a preparation method and application thereof. The invention provides a preparation method of an acetylbenzene compound shown as a formula III. The preparation method comprises the following step: in an organic solvent, in the presence of an acid and water, carrying out a deesterification reaction as shown in the specification on a 2-benzoyl malonate compound as shown in a formula I and/or a tautomer thereof to obtain the acetylbenzene compound as shown in a formula III, wherein X is F, Cl, Br or I; wherein R1 and R2 are each independently a C1-C4 alkyl group. By adopting the 2-benzoyl malonate compound disclosed by the invention, 4-halogenated-2-trifluoromethyl acetophenone can be prepared through one-step reaction, and the operation is simple and convenient.

Highly chemoselective intermolecular cross-benzoin reactions using an: Ad hoc designed novel N-heterocyclic carbene catalyst

The design of a novel N-heterocyclic carbene catalyst incorporating a bulky yet highly electron-deficient N-aryl substituent has allowed the development of an efficient protocol for the first highly chemoselective intermolecular benzoin condensations between two non-identical aromatic aldehydes.

Efficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines

The synthesis of highly functionalized substituted tetrahydro-1H-cyclopenta[c]quinoline (I) and its reduced derivatives hexahydro-1H-cyclopenta[c]quinolines (II) via Povarov reaction in high diastereoselectivity and high to moderate yields is described he