861966-46-3

Basic information

• Product Name: 2-(4-tert-butylbenzoyl)-3,3-bis-methylsulfanyl-acrylonitrile
• Synonyms: 2-(4-tert-butylbenzoyl)-3,3-bis-methylsulfanyl-acrylonitrile
• CAS NO: 861966-46-3
• Molecular Weight: 305.465
• Mol File: 861966-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-tert-butylbenzoyl)-3,3-bis-methylsulfanyl-acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-butylbenzoyl)-3,3-bis-methylsulfanyl-acrylonitrile(861966-46-3)
• EPA Substance Registry System: 2-(4-tert-butylbenzoyl)-3,3-bis-methylsulfanyl-acrylonitrile(861966-46-3)

Safety Data

• Hazardous Substances Data: 861966-46-3(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 39528-62-6 3-(4-tert-butylphenyl)-3-oxopropanenitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 913555-41-6 3-(4-tert-butyl-phenyl)-4-cyano-5-pyrrolidin-1-yl-thiophene-2-carboxylic acid ethyl ester 
• 918121-68-3 3-(4-tert-butyl-phenyl)-4-cyano-5-phenylsulfanyl-thiophene-2-carboxylic acid ethyl ester 
• 861967-38-6 3-(4-tert-butyl-phenyl)-4-cyano-5-propylsulfanyl-thiophene-2-carboxylic acid ethyl ester 
• 861967-88-6 3-(4-tert-butyl-phenyl)-4-cyano-5-methanesulfonyl-thiophene-2-carboxylic acid ethyl ester 
• 861967-39-7 3-(4-tert-butyl-phenyl)-4-cyano-5-isopropylsulfanyl-thiophene-2-carboxylic acid ethyl ester 
• 861967-36-4 3-(4-tert-butyl-phenyl)-4-cyano-5-ethylsulfanyl-thiophene-2-carboxylic acid ethyl ester 
• 913555-43-8 3-(4-tert-butyl-phenyl)-4-cyano-5-methanesulfinyl-thiophene-2-carboxylic acid ethyl ester 
• 913555-40-5 3-(4-tert-butyl-phenyl)-4-cyano-5-dimethylamino-thiophene-2-carboxylic acid ethyl ester 
• 861967-22-8 3-(4-tert-butyl-phenyl)-4-cyano-5-ethyl-thiophene-2-carboxylic acid ethyl ester 
• 861960-45-4 3-(4-tert-butyl-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid 
• 913555-42-7 3-(4-tert-butyl-phenyl)-4-cyano-thiophene-2-carboxylic acid ethyl ester 
• 861967-94-4 3-(4-tert-butyl-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester 

Relevant articles and documents

A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives

The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (6a) are described. SAR studies at the thioether moiety ind