862118-90-9

Basic information

• Product Name: Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-2-cyclohexyl-N-methyl- , (2S)-
• CAS NO: 862118-90-9
• Molecular Formula: C20H37N3O4
• Molecular Weight: 383.531
• Mol File: 862118-90-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-2-cyclohexyl-N-methyl- , (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-2-cyclohexyl-N-methyl- , (2S)-(862118-90-9)
• EPA Substance Registry System: Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-2-cyclohexyl-N-methyl- , (2S)-(862118-90-9)

Safety Data

• Hazardous Substances Data: 862118-90-9(Hazardous Substances Data)

Upstream product

• 862119-00-4 (S)-((S)-2-tert-butoxycarbonylamino-3,3-dimethylbutyrylamino)cyclohexylacetic acid methyl ester 
• 593-51-1 methylamine hydrochloride 
• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 107202-38-0 tert-butyl (S)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 145618-11-7 (S)-amino(cyclohexyl)acetic acid methyl ester 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 20859-02-3 L-tert-Leucine 
• 74-89-5 methylamine 

Downstream Products

• 959346-16-8 (1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester 
• 925240-48-8 (S)-2-(trans-N¹-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester 
• 925240-43-3 (S)-2-{[trans-2-{(S)-1-[((S)-cyclohexyl(methylcarbamoyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}butyric acid tert-butyl ester 
• 862119-02-6 (S)-2-amino-N-((S)-cyclohexyl(methylcarbamoyl)methyl)-3,3-dimethylbutyramide 

Relevant articles and documents

Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere

Potent tetrapeptidic inhibitors of the HCV NS3 protease have been developed incorporating 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a new N-acyl-l-hydroxyproline mimic. The hydroxycyclopentene template was synthesized in eight steps from commercially available (syn)-tetrahydrophthalic anhydride. Three different amino acids were explored in the P1-position and in the P2-position the hydroxyl group of the cyclopentene template was substituted with 7-methoxy-2-phenyl-quinolin-4-ol. The P3/P4-positions were then optimized from a set of six amino acid derivatives. All inhibitors were evaluated in an in vitro assay using the full-length NS3 protease. Several potent inhibitors were identified, the most promising exhibiting a Ki value of 1.1 nM.