862118-93-2

Basic information

• Product Name: Glycine, N-[(phenylmethoxy)carbonyl]-L-valyl-2-cyclohexyl-, methyl ester, (2S)-
• CAS NO: 862118-93-2
• Molecular Formula: C22H32N2O5
• Molecular Weight: 404.506
• Mol File: 862118-93-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(phenylmethoxy)carbonyl]-L-valyl-2-cyclohexyl-, methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(phenylmethoxy)carbonyl]-L-valyl-2-cyclohexyl-, methyl ester, (2S)-(862118-93-2)
• EPA Substance Registry System: Glycine, N-[(phenylmethoxy)carbonyl]-L-valyl-2-cyclohexyl-, methyl ester, (2S)-(862118-93-2)

Safety Data

• Hazardous Substances Data: 862118-93-2(Hazardous Substances Data)

Upstream product

• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 107202-38-0 tert-butyl (S)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 145618-11-7 (S)-amino(cyclohexyl)acetic acid methyl ester 

Downstream Products

• 925240-51-3 (1R,2S)-1-{[trans-2-{(S)-1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester 
• 862174-43-4 (S)-2-{[trans-2-{(S)-1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}butyric acid tert-butyl ester 
• 862175-07-3 (S)-2-{[(1S,4S)-{(S)-1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}pentanoic acid tert-butyl ester 
• 862174-48-9 (S)-2-{[(1R,4R)-{(S)-1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}pentanoic acid tert-butyl ester 
• 862175-13-1 (S)-((S)-2-amino-3-methylbutyrylamino)cyclohexylacetic acid methyl ester 

Relevant articles and documents

HCV NS-3 serine protease inhibitors

HCV inhibitors, compositions comprising these compounds as active ingredient, as well as processes for preparing these compounds, of formula: wherein A is

Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere

Potent tetrapeptidic inhibitors of the HCV NS3 protease have been developed incorporating 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a new N-acyl-l-hydroxyproline mimic. The hydroxycyclopentene template was synthesized in eight steps from commercially available (syn)-tetrahydrophthalic anhydride. Three different amino acids were explored in the P1-position and in the P2-position the hydroxyl group of the cyclopentene template was substituted with 7-methoxy-2-phenyl-quinolin-4-ol. The P3/P4-positions were then optimized from a set of six amino acid derivatives. All inhibitors were evaluated in an in vitro assay using the full-length NS3 protease. Several potent inhibitors were identified, the most promising exhibiting a Ki value of 1.1 nM.