862211-42-5

Basic information

• Product Name: N-[4-(2,3-epoxypropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline
• CAS NO: 862211-42-5
• Molecular Weight: 341.364
• Mol File: 862211-42-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-(2,3-epoxypropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2,3-epoxypropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline(862211-42-5)
• EPA Substance Registry System: N-[4-(2,3-epoxypropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline(862211-42-5)

Safety Data

• Hazardous Substances Data: 862211-42-5(Hazardous Substances Data)

Upstream product

• 106-89-8 epichlorohydrin 
• 680576-44-7 N-(4-hydroxyphenyl)-5,6-dimethoxy-1-oxo-isoindoline 
• 123-30-8 4-amino-phenol 
• 4821-94-7 4,5-dimethoxyphthalic anhydride 
• 862211-41-4 N-(4-hydroxyphenyl)-5,6-dimethoxyphthalimide 

Relevant articles and documents

Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)- substituted phenoxypropanolamines and their β1-, β2-adrenergic receptor binding studies

Phenoxypropanolamines with 1-oxo-isoindoline (12-16) and 5,6-dimethoxy-1-oxo-isoindoline groups (17-20) at the para position were synthesized. β1, β2-Adrenergic receptor binding affinities for the synthesized compounds were tested and compared with propranolol and atenolol. It was found that the incorporation of para-amidic functionality within the 1-oxo-isoindoline ring and 5,6-dimethoxy-1-oxo- isoindoline ring system led to a high degree of cardioselectivity in the phenoxypropanolamines. Two of the compounds 12 and 20 possessed β1-adrenergic receptor affinity comparable with that of atenolol and both showed a better cardioselectivity than atenolol. Both 12 and 20 are undergoing further pharmacological evaluation.