862416-37-3 Usage
General Description
1-benzyl-3,3-difluoropyrrolidine hydrochloride, also known as BDPFH, is a chemical compound that contains a benzyl group and a difluoropyrrolidine ring. It is commonly used in pharmaceutical research as a building block in the synthesis of various drug molecules. The hydrochloride salt form of this compound allows for better solubility in aqueous solutions, making it easier to handle and administer in laboratory and clinical settings. BDPFH has potential applications in the development of new medications, particularly in the field of central nervous system disorders, due to its unique chemical structure and biological activities. Studies have shown that BDPFH exhibits promising properties as a potential treatment for various neurological and psychiatric conditions, making it an important target for further investigation and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 862416-37-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,2,4,1 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 862416-37:
(8*8)+(7*6)+(6*2)+(5*4)+(4*1)+(3*6)+(2*3)+(1*7)=173
173 % 10 = 3
So 862416-37-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H13F2N.ClH/c12-11(13)6-7-14(9-11)8-10-4-2-1-3-5-10;/h1-5H,6-9H2;1H
862416-37-3Relevant articles and documents
Practical preparation of 3,3-difluoropyrrolidine
Xu, Feng,Simmons, Bryon,Armstrong III, Joseph,Murry, Jerry
, p. 6105 - 6107 (2005)
A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH3·Me2S reduction.
