862422-88-6

Basic information

• Product Name: 2-[4-(3-benzylamino-2-hydroxy-propoxy)-phenyl]-acetamide
• CAS NO: 862422-88-6
• Molecular Weight: 314.384
• Mol File: 862422-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(3-benzylamino-2-hydroxy-propoxy)-phenyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(3-benzylamino-2-hydroxy-propoxy)-phenyl]-acetamide(862422-88-6)
• EPA Substance Registry System: 2-[4-(3-benzylamino-2-hydroxy-propoxy)-phenyl]-acetamide(862422-88-6)

Safety Data

• Hazardous Substances Data: 862422-88-6(Hazardous Substances Data)

Upstream product

• 17194-82-0 2-(4-hydroxyphenyl)acetamide 
• 29122-69-8 (S)-1-[p-(carbamoylmethyl)phenoxy]-2,3-epoxypropane 
• 100-46-9 benzylamine 

Relevant articles and documents

Design, synthesis and evaluation of racemic 1-(4-hydroxyphenyl)-2-[3- (substituted phenoxy)-2-hydroxy-1-propyl]amino-1-propanol hydrochlorides as novel uterine relaxants

Novel 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl] amino-1-propanol hydrochlorides were designed based on the pharmacophore for potent uterine relaxant activity and by utilizing the principles of structural hybridization. The designed molecules were synthesized as racemates by a novel route and were evaluated for uterine relaxant activity in vitro on isolated rat uterus and in vivo in pregnant rats. Their cAMP-releasing potential was studied using rat uterus tissue homogenates by the cAMP [3H] assay, and cardiac stimulant potential was evaluated on isolated guinea pig right atrium. All compounds exhibited potent uterine relaxant activity in vitro and produced a significant delay in the onset of labour in pregnant rats; their cAMP-releasing potential was slightly less, while their cardiac stimulant potential was insignificant as compared to isoxsuprine hydrochloride.