862682-63-1Relevant articles and documents
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Finlay, M. Raymond V.,Acton, David G.,Andrews, David M.,Barker, Andrew J.,Dennis, Michael,Fisher, Eric,Graham, Mark A.,Green, Clive P.,Heaton, David W.,Karoutchi, Galith,Loddick, Sarah A.,Morgentin, Remy,Roberts, Andrew,Tucker, Julie A.,Weir, Hazel M.
scheme or table, p. 4442 - 4446 (2009/04/06)
A piperazine series of cyclin-dependent kinase (CDK) inhibitors have been identified. The compounds exhibit excellent physiochemical properties and a novel binding mode, whereby a bridging interaction via a water molecule with Asp 86 of CDK2, leads to sel
