862814-75-3

Basic information

• Product Name: ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate
• Synonyms: ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate
• CAS NO: 862814-75-3
• Molecular Weight: 634.731
• Mol File: 862814-75-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate(862814-75-3)
• EPA Substance Registry System: ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate(862814-75-3)

Safety Data

• Hazardous Substances Data: 862814-75-3(Hazardous Substances Data)

Upstream product

• 24521-76-4 6-thioxo-1,5,6,7-tetrahydropyrazolo<3,4-d>pyrimidin-4-one 
• 535-11-5 Ethyl 2-bromopropionate 
• 5334-32-7 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 
• 380897-71-2 (3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide 
• 862785-89-5 ethyl α-[6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate 

Relevant articles and documents

Synthesis and biological evaluation of some α-[6-(1′- carbamoylalkylthio)-1 H-pyrazolo[3,4-D]pyrimidin-4-yl]thioalkylcarboxamide acyclonucleosides

The reaction of 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 11 with compounds 12a-c produces ethyl α-[6-(1′-carboethoxyalkylthio)-1 H-pyrazolo[3,4-d]pyrimidin-4-yl]thioalkylates 13a-c, respectively. These heterocycles were alkylated, separately, with alkylating agents 14, 15, and 16 to afford, predominately, the N1-acyclic nucleosides (17-19)a-c, which were deprotected to give the desired products (20-22)a-c. All synthetic compounds were characterized on the basis of their physical and spectroscopic properties. The acyclic nucleosides (20-22)a-c were evaluated for their inhibitory effects against the replication of varicella-zoster virus, human cytomegalovirus and M. tuberculosis. No marked biological activity was found. Copyright Taylor & Francis Group, LLC.