862877-68-7

Basic information

• Product Name: (-)-(2S,6E)-8-benzyloxy-2-hydroxy-2,6-dimethyloct-6-en-3-one
• Synonyms: (-)-(2S,6E)-8-benzyloxy-2-hydroxy-2,6-dimethyloct-6-en-3-one
• CAS NO: 862877-68-7
• Molecular Weight: 292.375
• Mol File: 862877-68-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(2S,6E)-8-benzyloxy-2-hydroxy-2,6-dimethyloct-6-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(2S,6E)-8-benzyloxy-2-hydroxy-2,6-dimethyloct-6-en-3-one(862877-68-7)
• EPA Substance Registry System: (-)-(2S,6E)-8-benzyloxy-2-hydroxy-2,6-dimethyloct-6-en-3-one(862877-68-7)

Safety Data

• Hazardous Substances Data: 862877-68-7(Hazardous Substances Data)

Upstream product

• 862877-74-5 (+)-(2R,6E)-2,2-dimethylpropionic acid 8-benzyloxy-2-hydroxy-2,6-dimethyl-3-oxo-oct-6-enyl ester 
• 40036-54-2 (E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-en-1-ol 
• 130826-84-5 (2E)-acetic acid 6-bromo-7-hydroxy-3,7-dimethyl-oct-2-enyl ester 
• 68690-78-8 (2E)-1-benzyloxy-6-hydroxy-3,7-dimethyl-2,7-octadiene 
• 105-87-3 3,7-dimethyl-2E,6-octadien-1-yl acetate 
• 55776-46-0 (3'E)-3-(5'-benzyloxy-3'-methylpent-3'-enyl)-2,2-dimethyloxirane 
• 862877-73-4 (+)-(2S,3R,6E)-2,2-dimethylpropionic acid 8-benzyloxy-2,3-dihydroxy-2,6-dimethyl-oct-6-enyl ester 
• 862877-65-4 (-)-(2'S,1R,4E)-6-benzyloxy-4-methyl-1-(2'-methyloxiranyl)-hex-4-en-1-ol 

Downstream Products

• 862877-71-2 (-)-(2S,6E)-(diethoxyphosphoryl)acetic acid 8-benzyloxy-2,6-dimethyl-3-oxo-2-trimethylsilanyloxy-oct-6-enyl ester 
• 862877-69-8 (-)-(2S,6E)-(diethoxyphosphoryl)acetic acid 8-benzyloxy-2-hydroxy-2,6-dimethyl-3-oxo-oct-6-enyl ester 

Relevant articles and documents

Studies on the synthesis of DNA-damaging part of leinamycin: Regioselectivity in Ti(OiPr)4 mediated opening of hydroxy epoxides with carboxylic acids

The preparation of the key intermediate in the synthesis of the DNA damaging fragment of the anticancer antibiotic leinamycin starting from geraniol is described. The synthetic sequence involves the building of a quaternary asymmetric center through kinetic resolution through Sharpless epoxidation followed by the regioselective opening of the resultant enantiomerically pure hydroxyepoxide and intramolecular Wittig-Horner olefination.