862906-94-3Relevant articles and documents
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure
Jaye, Michael C.,Krawiec, John A.,Campobasso, Nino,Smallwood, Angela,Qiu, Chunyan,Lu, Quinn,Kerrigan, John J.,De Los Frailes Alvaro, Maite,Laffitte, Bryan,Liu, Wu-Schyong,Marino Jr., Joseph P.,Meyer, Craig R.,Nichols, Jason A.,Parks, Derek J.,Perez, Paloma,Sarov-Blat, Lea,Seepersaud, Sheila D.,Steplewski, Klaudia M.,Thompson, Scott K.,Wang, Ping,Watson, Mike A.,Webb, Christine L.,Haigh, David,Caravella, Justin A.,Macphee, Colin H.,Willson, Timothy M.,Collins, Jon L.
, p. 5419 - 5422 (2005)
Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 (4) as an LXR ligand. 4 r
