863-81-0Relevant articles and documents
CONVENIENT METHOD OF SYNTHESIZING THE METHYL ETHER OF BENZOIN.
Etlis,Shomina
, p. 1770 - 1772 (2007/10/02)
The authors propose a convenient method of synthesizing the methyl ether of benzoin, which makes possible an appreciable reduction in the total volume of organic solvents, quickens the process and delivers a product with high yield and high purity. Benzoin was synthesized by condensing benzaldehyde in a water-alcohol medium at 50-70 degree C with an equimolar mixture of acetone cyanohydrin and an alkali being used as the catalyst at the rate of 8-12% of the benzaldehyde. The reaction takes 1 h to give a 90-92% yield of benzoin. It is shown that the best results were obtained when 1,4-dioxane was used as the solvent, the optimum being the use of 1 mole of dioxane to 0. 1 mole of benzoin with a methanol:benzoin molar ratio of 1:30, whereupon, at 60 degree C, the compound is formed in 3. 5 h with the maximum yield and purity. To purify the product a single recrystallization from hexane is sufficient, whereas one of the disadvantages of the Fischer method is the complication of isolating compound (I) by repeated crystallization from nonane.
