863605-34-9

Basic information

• Product Name: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE;1H-Pyrazole, 4-bromo-3-(4-fluorophenyl)-1-methyl-;EOS-62021
• CAS NO: 863605-34-9
• Molecular Formula: C₁₀H₈BrFN₂
• Molecular Weight: 255.0863232
• Mol File: 863605-34-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 315.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: -0.49±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(863605-34-9)
• EPA Substance Registry System: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(863605-34-9)

Safety Data

• Hazardous Substances Data: 863605-34-9(Hazardous Substances Data)

Usage

Description

4-Bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole is a pyrazole derivative with the molecular formula C10H8BrFN2. It features a bromo group at the 4-position, a methyl group at the 1-position, and a 4-fluorophenyl group at the 3-position. This chemical compound serves as a building block in the synthesis of various organic compounds and holds potential for use in the development of new drugs and agrochemicals.

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole is utilized as a building block for the creation of a variety of organic compounds, contributing to the advancement of chemical research and product development.
Used in Agrochemical Development:
4-Bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole may also be employed in the development of agrochemicals, where its properties could be harnessed to create new products for agricultural applications, such as pesticides or herbicides.
Safety Precautions:
As with any chemical compound, it is essential to follow proper handling and safety procedures when working with 4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole to ensure the safety of individuals and the environment.

Upstream product

• 154258-82-9 3-(4-fluorophenyl)-1H-pyrazole 
• 474706-36-0 4-bromo-3-(4-fluorophenyl)-1H-pyrazole 
• 74-88-4 methyl iodide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 75175-77-8 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 
• 863605-35-0 3-(4'-fluorophenyl)-1-methylpyrazole 

Downstream Products

• 1383377-50-1 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile 
• 1383376-98-4 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine 
• 1383377-64-7 tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate 
• 1286230-78-1 3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 1383376-92-8 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one 
• 1383376-96-2 6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1383377-63-6 6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 1383376-97-3 6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 1383377-66-9 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one 
• 1383377-68-1 tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate 
• 1383377-01-2 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-(methylsulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 1383377-14-7 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 1383377-17-0 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-[(1-methyl-1H-pyrazol-4-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1383377-49-8 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride 

Relevant articles and documents

Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity

A series of fluorophenylpyrazole-picolinamide derivatives were synthesized in high yields using a cross-coupling reaction catalyzed by in situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). The synthesized novel derivatives were evaluated for in vitro anticancer activity against a panel of four human tumor cell lines, HeLa (cervical), A-549 (lung), MCF-7 (breast), and IMR-32 (neuroblastoma). Four compounds, 11c, 11e, 11j, and 11k, showed growth inhibition (low μM) comparable with the standard drug cisplatin, providing a preliminary structure–activity relationship for the series. The present procedure is operationally simple and works with a wide range of substrates and may thus be useful in further compound optimization.

PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.