86386-76-7

Basic information

• Product Name: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole
• Synonyms: 1-[2-(2,4-Difluorophenyl)-oxiranyl]-methyl-1H-1,2,4-triazole;2-(2,4-Difluorophenyl)-2,3-epoxy-1-(1H-1,2,4-triazol-1-yl)propane;2-(2,4-Difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)Methyl]oxirane;Fluconazole Epoxy IMpurity;1 (-2-(2,4- DIFLUOROPHNEYL)-2,3- EPOXY PROPYL)-1H-1,2,4- TRIAZOLE METHANE SULFONATE;1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole;l-[2-(2,4-Difluoro Phenyl)Oxiranyl] Methyl-lH-1,2,4-Triazole;Fluconazole EP Impurity G
• CAS NO: 86386-76-7
• Molecular Formula: C₁₁H₉F₂N₃O
• Molecular Weight: 237.2054664
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 86386-76-7.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 370.474°C at 760 mmHg
• Flash Point: 177.857°C
• Appearance: /
• Density: 1.464g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Hexanes (Sligh
• CAS DataBase Reference: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole(86386-76-7)
• EPA Substance Registry System: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole(86386-76-7)

Safety Data

• Hazardous Substances Data: 86386-76-7(Hazardous Substances Data)

Usage

Description

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole, also known as Fluconazole EP Impurity G, is an epoxy impurity derived from the antifungal agent Fluconazole (F421000). It is characterized by its white solid appearance.

Uses

Used in Pharmaceutical Industry:
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole is used as an impurity in the production of the antifungal agent Fluconazole (F421000) for its antifungal properties. It plays a role in the synthesis process of Fluconazole, contributing to its effectiveness in treating fungal infections.

InChI:InChI=1/C11H9F2N3O/c12-8-1-2-9(10(13)3-8)11(5-17-11)4-16-7-14-6-15-16/h1-3,6-7H,4-5H2

Upstream product

• 1030268-24-6 trimethylsulphoxonium iodide 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 70775-39-2 dimethylsulfoxonium methylide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 372-18-9 1,3-Difluorobenzene 
• 2181-42-2 trimethylsulphonium iodide 
• 57-09-0 cetyltrimethylammonim bromide 
• 118689-07-9 (S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 

Downstream Products

• 146796-52-3 2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol 
• 132507-80-3 1?azido?2?(2,4?difluorophenyl)?3?(1H?1,2,4?triazol?1?yl)propan?2?ol 
• 205435-16-1 1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-1-ethyl-1-methylhydrazinium inner salt 
• 205434-84-0 1-amino-1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]hexahydropyridinium inner salt 
• 205434-82-8 1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-1,1-dimethylhydrazinium inner salt 

Relevant articles and documents

Voriconazole synthesis process

The invention discloses a synthesis process of voriconazole bulk drug, which comprises the following steps: preparing halogenated ethyl fluorouracil and carrying out Grignard reaction. 2 - (2, 4 - Difluorophenyl) -3 - (1, 2, 4 - triazol -1 -yl) -1, 2 - propylene glycol was oxidized to give a propylene oxide compound. The Grignard reagent and the propylene oxide compound are mixed and reacted to obtain voriconazole. To the synthesis process, the reaction steps can be simplified, the dehydrochlorination and hydrogenolysis of palladium carbon are not needed, the reaction period is shortened, and furthermore, the energy consumption is reduced, the cost is reduced, and voriconazole and the racemate thereof are obtained with higher yield.

TRIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, Q2, L1 and n are as defined herein. The compounds have antifungal properties and are useful in the treatment of fungal infections, including infections that are resistant to conventions anti-fungal agents. Q1 is selected from: (Formulae Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik) wherein * indicates the point of attachment to L1.

Antibacterial drug and preparation method thereof

The invention discloses an antibacterial drug. The antibacterial drug is 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(1H-1,2,3,4-tetrazol-1-yl)-2-propanol, the compound is obtained by modifyingfluconazole and introducing a tetrazole ring. Compared with fluconazole, the compound has wider antimicrobial activity spectrum. The invention also discloses a preparation method of the antibacterialdrug. The method comprises the step of introducing the tetrazole ring to obtain 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(1H-1,2,3,4-tetrazol-1-yl)-2-propanol on the basis of retaining moststructures with drug effects on fluconazole.