863971-62-4 Usage
Description
Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II), min. 98% (Milstein Catalyst Precursor) is a complex organometallic compound that serves as a precursor to an active ruthenium catalyst. This catalyst plays a crucial role in facilitating greener chemical reactions, specifically in the formation of amide bonds through dehydrogenative coupling of amines and alcohols. Its unique structure, which includes a ruthenium center coordinated to a carbonyl, hydrido, and a phosphine ligand, along with a modified pyridine ligand, endows it with the ability to efficiently catalyze these reactions with the liberation of hydrogen gas (H2), making it an environmentally friendly alternative to traditional methods.
Uses
Used in Green Chemistry:
Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II), min. 98% (Milstein Catalyst Precursor) is used as a precursor to an active ruthenium catalyst for greener amide bond formation. This is achieved through the dehydrogenative coupling of amines and alcohols, which allows for the synthesis of amides with the liberation of hydrogen gas (H2) as the only byproduct. This approach significantly reduces the environmental impact and waste associated with traditional amide bond formation methods.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II), min. 98% (Milstein Catalyst Precursor) is utilized as a key component in the development of ruthenium-based catalysts for the synthesis of amides. Amides are essential structural elements in many pharmaceutical compounds, and their efficient and environmentally friendly synthesis is crucial for the production of new drugs and the improvement of existing ones.
Used in Chemical Research:
Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II), min. 98% (Milstein Catalyst Precursor) is also used in chemical research as a catalyst precursor for studying new reaction pathways and mechanisms. Its ability to facilitate the dehydrogenative coupling of amines and alcohols to form amides provides a valuable tool for researchers to explore novel synthetic methods and develop more sustainable chemical processes.
Used in Direct Synthesis of Amides:
Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II), min. 98% (Milstein Catalyst Precursor) is used as a catalyst precursor for the direct synthesis of amides from alcohols and amines with the liberation of H2. This method offers a more sustainable and efficient approach to amide synthesis, as it avoids the use of harmful reagents and reduces the environmental impact associated with traditional methods. The direct synthesis of amides using this catalyst precursor has the potential to revolutionize the way amides are produced in various industries, including pharmaceuticals, agrochemicals, and materials science.
Reaction
Ruthenium catalyst for the direct synthesis of amides from alcohols and primary amines.
Ruthenium catalyst for the hydrogenation of esters in high yields under mild pressure and neutral conditions.
Ruthenium catalyst for the dehydrogenative coupling of alcohols to form esters in high yields under neutral conditions.
Ruthenium catalyst for the synthesis of amides from esters and amines with liberation of hydrogen gas.
Ruthenium catalyst for the hydrogenation of 3-methyl-2-oxalidinone
Check Digit Verification of cas no
The CAS Registry Mumber 863971-62-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,3,9,7 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 863971-62:
(8*8)+(7*6)+(6*3)+(5*9)+(4*7)+(3*1)+(2*6)+(1*2)=214
214 % 10 = 4
So 863971-62-4 is a valid CAS Registry Number.
