863991-04-2

Basic information

• Product Name: tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate
• Synonyms: tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate;tert-Butyl (2S)-2-[(aminooxy)methyl]pyrrolidine-1-carboxylate
• CAS NO: 863991-04-2
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.2774
• EINECS: -0
• Mol File: 863991-04-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate(863991-04-2)
• EPA Substance Registry System: tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate(863991-04-2)

Safety Data

• Hazardous Substances Data: 863991-04-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate is a chemical compound that is commonly used in organic chemistry research and pharmaceutical development. It is a derivative of pyrrolidine and contains an aminooxy group which can be utilized for various synthetic reactions and chemical modifications. tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate is often employed as a building block in the synthesis of complex molecules due to its high reactivity and stability. Additionally, its tert-butyl group provides increased solubility in organic solvents and improved handling properties. Overall, tert-butyl (S)-2-((aminooxy)methyl)pyrrolidine-1-carboxylate is a versatile and valuable tool for the creation of novel compounds with potential applications in various industries.

Upstream product

• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 952747-36-3 tert-butyl (2S)-2-[[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]methyl]-pyrrolidine-1-carboxylate 
• 147-85-3 L-proline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 952747-32-9 (S)-2-pyrrolidinylmethoxyamine dihydrochloride 

Relevant articles and documents

BETA-LACTAMASE INHIBITOR COMPOUNDS

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta- lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R2, R3, R4, R5 and R6 are described herein.

1,6- DIAZABICYCLO [3,2,1] OCTAN-7-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS

Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

Novel analogues of istaroxime, a potent inhibitor of Na+,K +-ATPase: Synthesis and structure-activity relationship

We report the synthesis and biological properties of novel inhibitors of the Na+,K+-ATPase as positive inotropic compounds. Following our previously described model from which Istaroxime was generated, the 5α,14α-androstane skeleton was used as a scaffold to study the space around the basic chain of our lead compound. Some compounds demonstrated higher potencies than Istaroxime on the receptor and the (E)-3-[(R)-3- pyrrolidinyl]oxime derivative, 15, was the most potent; as further confirmation of our model, the E isomers of the oxime are more potent than the Z form. The compounds tested in the guinea pig model induced positive inotropic effects, which are correlated to the in vitro inhibitory potency on the Na +,K+-ATPase. The finding that all tested compounds resulted less proarrhythmogenic than digoxin, a currently clinically used positive inotropic agent, suggests that this could be a feature of the 3-aminoalkyloxime derivative class of 5α,14α-androstane.