86426-00-8Relevant articles and documents
Mukaiyama aldol reactions catalyzed by a trimeric organo aluminum(III) alkoxide
Kim, So Han,Yoon, Sungwoo,Kim, Youngjo,Verkade, John G.
, p. 1193 - 1206 (2014/09/30)
Mukaiyama aldol reactions of enol ethers with a variety of aldehydes and ketones are efficiently catalyzed at 0-25 °C by the sterically bulky trimeric organo aluminum(III) alkoxide 1 synthesized via the reaction of 3 equiv of AlMe3 with tripodal tris(2-hydroxy-3-tert-butyl-5-methylphenyl) methane and the elimination of 3 equiv of methane. Comparisons of its catalytic properties with the less sterically hindered analogue 2, the more sterically hindered analogue 3, a monomeric aluminum near-analogue 4, and a dimeric alumatrane 5 revealed that 1 possesses superior activity.
Sodium phenoxide-phosphine oxides as extremely active Lewis base catalysts for the Mukaiyama aldol reaction with ketones
Hatano, Manabu,Takagi, Eri,Ishihara, Kazuaki
, p. 4527 - 4530 (2008/03/12)
(Chemical Equation Presented) A highly efficient Mukaiyama aldol reaction between ketones and trimethylsilyl enolates catalyzed by sodium phenoxide-phosphine oxides as simple homogeneous Lewis base catalysts (0.5-10 mol %) was developed, which minimized c
SILYL KETENE ACETAL CHEMISTRY: STERIC LIMITATIONS IN LEWIS ACID-PROMOTED ADDITION OF KETONES
Wenke, G.,Jacobsen, E. N.,Totten, G. E.,Karydas, A. C.,Rhodes, Y. E.
, p. 449 - 458 (2007/10/02)
Lewis acid-promoted additions of ketones to silyl ketene acetals is limited sterically with α-branched alkyl groups in the ketone.Cyclic ketones give high yields.Titanium, ferric and aluminum chlorides are effective catalysts.
