86428-59-3

Basic information

• Product Name: Cyclohexanone, 4-(2-oxopropyl)-
• CAS NO: 86428-59-3
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol File: 86428-59-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-(2-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(2-oxopropyl)-(86428-59-3)
• EPA Substance Registry System: Cyclohexanone, 4-(2-oxopropyl)-(86428-59-3)

Safety Data

• Hazardous Substances Data: 86428-59-3(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 65700-06-3 percarbonate de O,O-tert-butyle et O-isopropyle 
• 66405-39-8 4-(2-hydroxypropyl)cyclohexan-1-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 643028-47-1 4-(2-hydroxypropyl)cyclohexan-1-ol 
• 770-39-8 4-methoxyphenylacetone 
• 124499-35-0 2-<4,4-(ethylenedioxy)cyclohexylidene>acetonitrile 
• 124499-37-2 1,4-dioxaspiro[4.5]dec-8-yl acetonitrile 

Relevant articles and documents

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Site selectivity, differentiating instances of the same functional group type on one substrate, represents a forward-looking theme within chemistry: reduced dependence on protection/deprotection protocols for increased overall yield and step-efficiency. Despite these potential benefits and the expanded tactical advantages afforded to synthetic design, site selectivity remains elusive and especially so for ketone-based substrates. Herein, site-selective intermolecular mono-aldolization has been demonstrated for an array of prochiral 4-keto-substituted cyclohexanones with concomitant regio-, diastereo-, and enantiocontrol. Importantly, the aldol products allow rapid access to molecularly complex ketolactones or keto-1,3-diols, respectively containing three and four stereogenic centers. The reaction conditions are of immediate practical value and general enough to be applicable to other reaction types. These findings are applied in the first enantioselective, formal, synthesis of a leading Alzheimer's research drug, a γ-secretase modulator (GSM), in the highest known yield.

Drastic ring transformation reactions of fused bicyclic rings to bridged bicyclic rings

By treatment with BF3-etheratelethylene glycol, cyclohexanone with a carbonyl function at the 2′-(or 3′-) position of γ-side chain underwent novel ring transformation to afford five- (or six-) membered rings, and the fused bicyclic rings (bicyc

Reactions radicalaires du percarbonate de O,O-tert-butyle et O-isopropenyle: acetonylations assistees par un co-amorceur

By decomposition in alkanes, ethers, ketones, acids, esters and nitriles of equimolecular mixtures of O,O-tert-butyl and O-isopropenyl peroxicarbonate and tert-butyl peroxyacetate, the "assisted" acetonylation of the solvents has been accomplished.The presence of the co-initiator allows the yield of the free radical acetonylation to be markedly improved: the formation of the by-product acetonylacetone is avoided and the yield of acetonylated derivatives is strongly enhanced while the regioselectivity of the processes is preserved and even increased in some cases.