86457-14-9Relevant articles and documents
1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors
Luebbers, Thomas,Boehringer, Markus,Gobbi, Luca,Hennig, Michael,Hunziker, Daniel,Kuhn, Bernd,Loeffler, Bernd,Mattei, Patrizio,Narquizian, Robert,Peters, Jens-Uwe,Ruff, Yves,Wessel, Hans Peter,Wyss, Pierre
, p. 2966 - 2970 (2008/02/11)
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimizatio