86465-33-0 Usage
General Description
2H-Benzimidazol-2-one,6-chloro-1,3-dihydro-1-methoxy-(9CI) is a chemical compound with the molecular formula C10H10ClN2O2. It is a derivative of benzimidazole, which is a heterocyclic compound with a bicyclic structure. This specific derivative contains a chlorine and a methoxy group, making it a halogenated and methoxylated benzimidazole. Benzimidazoles and their derivatives have various pharmaceutical and biological activities, including anticancer, antiviral, and antifungal properties. The 6-chloro-1,3-dihydro-1-methoxy substituents on the benzimidazole core may impart specific pharmacological activities to this compound, making it a potential candidate for drug development and research.
Check Digit Verification of cas no
The CAS Registry Mumber 86465-33-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,6 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 86465-33:
(7*8)+(6*6)+(5*4)+(4*6)+(3*5)+(2*3)+(1*3)=160
160 % 10 = 0
So 86465-33-0 is a valid CAS Registry Number.
86465-33-0Relevant articles and documents
Catalytic substitution/cyclization sequences of: O -substituted Isocyanates: Synthesis of 1-alkoxybenzimidazolones and 1-alkoxy-3,4-dihydroquinazolin-2(1 H)-ones
Wang, Qiang,An, Jing,Alper, Howard,Xiao, Wen-Jing,Beauchemin, André M.
supporting information, p. 13055 - 13058 (2017/12/15)
O-Substituted isocyanates (O-isocyanates) have rarely been used in organic synthesis, given their tendency to undergo side reactions (e.g., trimerization). Herein, we show that masked (blocked) O-isocyanate precursors allow one-pot or cascade reaction sequences featuring base-catalyzed substitution with 2-iodoanilines and 2-iodobenzylamines followed by copper-catalyzed cyclization, to form benzimidazolones and 3,4-dihydroquinazolin-2(1H)-ones. This work shows that O-isocyanates can serve as efficient building blocks for the synthesis of hydroxylamine-containing heterocycles.
