864756-35-4

Basic information

• Product Name: 4-[(4-fluorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one
• CAS NO: 864756-35-4
• Molecular Weight: 408.473
• Mol File: 864756-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[(4-fluorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-fluorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one(864756-35-4)
• EPA Substance Registry System: 4-[(4-fluorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one(864756-35-4)

Safety Data

• Hazardous Substances Data: 864756-35-4(Hazardous Substances Data)

Usage

Uses

TC-MCH 7c is a potent melanin-concentrating hormone 1 receptor antagonist.

Upstream product

• 99522-34-6 4-[(tetrahydro-2H-pyran-2-yl)oxy]iodobenzene 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 459-56-3 4-fluorobenzylic alcohol 
• 864758-12-3 4-hydroxy-1-(4-[2-(pyrrolidin-1-yl)ethoxy]phenyl)-pyridin-2(1H)-one 
• 864757-74-4 4-(benzyloxy)-1-(4-hydroxyphenyl)pyridin-2(1H)-one 
• 864757-75-5 4-(benzyloxy)-1-[4-(tetrahydro-2H-pyran-2-yloxy)-phenyl]pyridin-2(1H)-one 

Relevant articles and documents

Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists

The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c, exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.