864770-82-1

Basic information

• Product Name: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
• Synonyms: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester;1-N-Boc-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3-Methyl-indazole;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester;tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;(1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 864770-82-1
• Molecular Formula: C₁₉H₂₇BN₂O₄
• Molecular Weight: 358.243
• Mol File: 864770-82-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 476℃
• Flash Point: 242℃
• Appearance: /
• Density: 1.12
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester(864770-82-1)
• EPA Substance Registry System: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester(864770-82-1)

Safety Data

• Hazardous Substances Data: 864770-82-1(Hazardous Substances Data)

Usage

General Description

1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester is a specialized chemical compound that belongs to a category of organic compounds known as indazoles. This specific compound contains boron, nitrogen and carbon atoms in its molecular structure, and is used mainly in scientific research rather than in practical applications. The presence of the 'Boc' group signifies that it has undergone Boc protection, a common method used in chemistry to protect amines. The pinacol ester part of the name implies that it is a boronic ester, which suggests that it can potentially be involved in certain types of coupling reactions, such as Suzuki-Miyaura coupling reactions in synthetic chemistry. As a research-level chemical, information about its exact uses and properties may not be widely available to the public.

InChI:InChI=1S/C19H27BN2O4/c1-12-14-11-13(20-25-18(5,6)19(7,8)26-20)9-10-15(14)22(21-12)16(23)24-17(2,3)4/h9-11H,1-8H3

Upstream product

• 552331-49-4 tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 552331-16-5 5-bromo-3-methyl-1H-indazole 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 552331-15-4 1-(5-bromo-2-fluorophenyl)ethan-1-ol 
• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 552332-08-8 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester 
• 1300585-05-0 2-(1-(4-amino-3-(3-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one 

Relevant articles and documents

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer

A novel series of pyridin-3-amine derivatives were designed, synthesized, and evaluated as multitargeted protein kinase inhibitors for the treatment of non-small cell lung cancer (NSCLC). Hit 1 was first disclosed by in silico screening against fibroblast

2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity

2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1 structures. Substitution at the 2-position of the core pyridine is the key element to provide selectivity against ROCK1. An X-ray co-crystal structure of 9p in PKA supports the proposed rationale of ROCK1 selectivity.