864774-67-4

Basic information

• Product Name: 5-BROMO-3-ETHYL-1H-INDAZOLE
• Synonyms: 5-BROMO-3-ETHYL-1H-INDAZOLE;1H-Indazole, 5-broMo-3-ethyl-;5-bromo-3-ethyl-2H-indazole
• CAS NO: 864774-67-4
• Molecular Formula: C₉H₉BrN₂
• Molecular Weight: 225.09
• Product Categories: Indazoles
• Mol File: 864774-67-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 350.923 °C at 760 mmHg
• Flash Point: 166.033 °C
• Appearance: /
• Density: 1.562 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMO-3-ETHYL-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-ETHYL-1H-INDAZOLE(864774-67-4)
• EPA Substance Registry System: 5-BROMO-3-ETHYL-1H-INDAZOLE(864774-67-4)

Safety Data

• Hazardous Substances Data: 864774-67-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-ethyl-1H-indazole is a chemical compound with the molecular formula C9H9BrN2. It is a brominated indazole derivative and is commonly used as a building block in organic synthesis and pharmaceutical research. 5-BROMO-3-ETHYL-1H-INDAZOLE has been studied for its potential applications in the development of new drugs, particularly in the field of medicinal chemistry. It is of interest due to its unique chemical structure, which may offer novel biological activities and pharmacological properties. Additionally, 5-Bromo-3-ethyl-1H-indazole is used as a reference standard in analytical chemistry for the identification and quantification of indazole derivatives in various samples.

InChI:InChI=1/C9H9BrN2/c1-2-8-7-5-6(10)3-4-9(7)12-11-8/h3-5H,2H2,1H3,(H,11,12)

Upstream product

• 864774-65-2 1-(5-bromo-2-fluorophenyl)propane-1-one 
• 1197943-64-8 1-(5-bromo-2-fluorophenyl)propan-1-ol 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 910912-20-8 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 864774-69-6 3-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 
• 1346808-87-4 tert-butyl 3-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.

FLUORINATED 2,6-DIALKYL-3,5-DICYANO-4-(1H-INDAZOL-5-YL)-1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF

The present invention relates to novel fluorinated 2,6-dialkyl-3,5-dicyano-4-(1H-indazol-5-yl)-1,4- dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the tre