864850-82-8

Basic information

• Product Name: N-[4-(hydroxymethyl)benzyl]-2-naphthamide
• Synonyms: N-[4-(hydroxymethyl)benzyl]-2-naphthamide
• CAS NO: 864850-82-8
• Molecular Weight: 291.349
• Mol File: 864850-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-(hydroxymethyl)benzyl]-2-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(hydroxymethyl)benzyl]-2-naphthamide(864850-82-8)
• EPA Substance Registry System: N-[4-(hydroxymethyl)benzyl]-2-naphthamide(864850-82-8)

Safety Data

• Hazardous Substances Data: 864850-82-8(Hazardous Substances Data)

Upstream product

• 39895-56-2 4-hydroxymethyl-benzylamine 
• 2243-83-6 2-naphthaloyl chloride 

Downstream Products

• 864850-86-2 4-[(2-naphthoylamino)methyl]benzyl imidothiocarbamate 
• 864850-84-0 N-[4-(bromomethyl)benzyl]-2-naphthamide 

Relevant articles and documents

Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G2/M arrest

Two compounds were synthesized which have a structural component other than those of our new series histone deacetylase (HDAC) inhibitors to determine the structure-activity relationship. It was also examined whether the inhibitory effects on cancer cell proliferation by HDAC inhibitors involve p21/WAF1 induction and G1 or G2/M arrest in p53-mutated MG63 human osteosarcoma cells as do other HDAC inhibitors. It was demonstrated that inhibitors with the 2-naphthylcarbonyl group and hydroxamic acid at both termimal sides as well as the phenylene component at the center of molecule markedly induce the p21/WAF1 protein by stimulating p21/WAF1 gene promoter activity. Furthermore, cell cycle analysis revealed that these compounds arrest MG63 cells in the G2/M phase.