864866-92-2

Basic information

• Product Name: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)
• Synonyms: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI);6-Bromo-2-methylisoquinolin-1(2H)-one;6-broMo-2-Methyl-1,2-dihydroisoquinolin-1-one;6-Bromo-2-methyl-2H-isoquinolin-1-one;6-Bromo-2-methylisoquinolin-1(2H)
• CAS NO: 864866-92-2
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.083
• Product Categories: QUINOLINONE
• Mol File: 864866-92-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 373°C at 760 mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 9.23E-06mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.50±0.70(Predicted)
• CAS DataBase Reference: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(864866-92-2)
• EPA Substance Registry System: 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI)(864866-92-2)

Safety Data

• Hazardous Substances Data: 864866-92-2(Hazardous Substances Data)

Usage

General Description

1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) is a chemical compound with the molecular formula C10H8BrNO. It is an isoquinolinone derivative with a bromine atom at the 6th position and a methyl group at the 2nd position. 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) has potential applications in the field of organic synthesis and medicinal chemistry due to its unique structure and reactivity. It can be used as a building block for the synthesis of various organic compounds and pharmaceuticals. Additionally, its functional groups make it a valuable intermediate in the production of diverse chemical products. 1(2H)-Isoquinolinone,6-bromo-2-methyl-(9CI) is of interest to researchers and chemists for its potential applications in the development of new drugs and materials.

InChI:InChI=1/C10H8BrNO/c1-12-5-4-7-6-8(11)2-3-9(7)10(12)13/h2-6H,1H3

Upstream product

• 74-88-4 methyl iodide 
• 82827-09-6 6-bromo-2H-isoquinoline-1-one 
• 34784-05-9 6-bromo-isoquinoline 

Relevant articles and documents

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT

Herein, we report two promising compounds 30 and 36 possessing nanomolar FLT3 inhibitory activities (IC50 = 1.5-7.2 nM), high selectivity over c-KIT (>1000-fold), and excellent anti-AML activity (MV4-11 IC50 = 0.8-3.2 nM). Furthermore, these two compounds efficiently inhibited the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y. Oral administration of 30 and 36 at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5% and 95.1%, respectively. Importantly, 36 could prolong the mouse survival time in the FLT3-ITD-TKD dual mutation syngeneic mouse model (BaF3-FLT3-ITD-D835Y) at a dose of 6 mg/kg p.o. bid/4W. No clear myelosuppression was observed in the treated group of 36 in the MPO strain of zebrafish, even at 10 μM. In summary, our data demonstrated that 36 may represent a promising candidate for the treatment of FLT3 mutant AML.

Harnessing selective PET and EnT catalysis by chlorophyll to synthesizeN-alkylated quinoline-2(1H)-ones, isoquinoline-1(2H)-ones and 1,2,4-trioxanes

Photocatalytic syntheses of quinoline-2(1H)-ones, isoquinoline-1(2H)-ones and 1,2,4-trioxanes were achieved by selective photo-induced electron transfer (PET) and energy transfer (EnT), respectively, by chlorophyll under visible light irradiation. Quinoli

Deprotonated Salicylaldehyde as Visible Light Photocatalyst

Salicylaldehyde is established as an efficient visible light photocatalyst for the first time. Compared to other simple aldehyde analogies, salicylaldehyde has a unique deprotonative red-shift from 324 to 417 nm and gives rise to the remarkable increase of fluorescence quantum from 0.0368 to 0.4632, thus enabling salicylaldehyde as a visible light (>400 nm) photocatalyst. The experimental investigations suggest that the reactive radical species are generated by sensitization of the substrates by the deprotonated salicylaldehyde through an energy-transfer pathway. Consequently, the C-C cleaving alkylation reactions of N-hydroxyphthalimide esters proceed smoothly in the presence of as low as 1 mol % of salicylaldehyde under the visible-light irradiation, affording desired alkylation products with up to 99% yields. Application in visible-light induced aerobic oxidation of N-alkylpyridinium salts is also reported.