865156-68-9

Basic information

• Product Name: 6-Bromo-imidazo[1,2-a]pyrimidine
• Synonyms: 6-Bromo-imidazo[1,2-a]pyrimidine;6-bromo-imidazo[1,2-a]pyr...;6-bromo-4-hydroimidazo[1,2-a]pyrimidine
• CAS NO: 865156-68-9
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.02006
• Product Categories: Building Blocks;Imidazo[x,x-y]pyridine;Heterocycle-Pyrimidine series
• Mol File: 865156-68-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 215-216°
• Boiling Point: 215-216 °C
• Appearance: /
• Density: 1.89 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.80±0.30(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 6-Bromo-imidazo[1,2-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-imidazo[1,2-a]pyrimidine(865156-68-9)
• EPA Substance Registry System: 6-Bromo-imidazo[1,2-a]pyrimidine(865156-68-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 865156-68-9(Hazardous Substances Data)

Usage

General Description

6-Bromo-imidazo[1,2-a]pyrimidine is a chemical compound with the molecular formula C5H3BrN4. It is a heterocyclic compound that contains both nitrogen and bromine atoms in its structure. This chemical is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of various biologically active compounds. Its heterocyclic structure makes it a valuable intermediate in the development of new drugs and crop protection agents. Additionally, 6-Bromo-imidazo[1,2-a]pyrimidine has shown potential as an inhibitor of certain enzymes, making it a target for drug discovery and development. Its versatile reactivity and utility in medicinal and agricultural chemistry make it an important chemical compound in the field of organic synthesis.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 107-20-0 2-chloroethanal 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 915278-11-4 6-bromoimidazo[1,2-a]pyrimidinium hydrobromide 

Downstream Products

• 1205125-49-0 N-benzylimidazo[1,2-a]pyrimidin-6-amine 
• 1205125-38-7 N-(6-{[6-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)cyclopropanecarboxamide 
• 1205125-39-8 3-bromo-6-(3-fluorophenyl)imidazo[1,2-a]pyrimidine 
• 1205125-46-7 N-cyclohexylimidazo[1,2-a]pyrimidin-6-amine 
• 1205125-40-1 6-(3-fluorophenyl)imidazo[1,2-a]pyrimidine 

Relevant articles and documents

Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.