86518-68-5

Basic information

• Product Name: 1-BUTYL-4-HYDROXYPIPERIDINE
• Synonyms: N-BUTYL-4-HYDROXY-PIPERIDINE;1-BUTYL-4-HYDROXYPIPERIDINE;1-Butyl-4-piperidinol
• CAS NO: 86518-68-5
• Molecular Formula: C₉H₁₉NO
• Molecular Weight: 157.25
• Mol File: 86518-68-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 118-120℃ (13 Torr)
• Appearance: /
• Density: 0.952±0.06 g/cm3(Predicted)
• PKA: 14.89±0.20(Predicted)
• CAS DataBase Reference: 1-BUTYL-4-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BUTYL-4-HYDROXYPIPERIDINE(86518-68-5)
• EPA Substance Registry System: 1-BUTYL-4-HYDROXYPIPERIDINE(86518-68-5)

Safety Data

• Hazardous Substances Data: 86518-68-5(Hazardous Substances Data)

Usage

Chemical Structure

Piperidine derivative with a butyl group and a hydroxy group attached to the piperidine ring

Usage

Pharmaceutical intermediate

Applications

Synthesis of various drugs and pharmaceutical compounds

Role

Vital in the production of medications

Industry

Pharmaceutical industry

Additional Applications

Other industrial processes due to unique chemical properties

Upstream product

• 23081-86-9 1-n-butyl-4-piperidone 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 3619-66-7 diethyl 3,3’-(butylazanediyl)dipropanoate 
• 123-72-8 butyraldehyde 

Downstream Products

• 63905-81-7 diphenyl-acetic acid-(1-butyl-[4]piperidylester); hydrochloride 
• 912946-78-2 4-(1-Butyl-piperidin-4-yloxy)-3-methyl-benzonitrile 
• 912947-02-5 4-(1-butyl-piperidin-4-yloxy)-3,5-dimethyl-benzonitrile 
• 912946-80-6 4-(1-Butyl-piperidin-4-yloxy)-benzonitrile 
• 912947-04-7 4-(1-Butyl-piperidin-4-yloxy)-3-chloro-benzonitrile 
• 912946-76-0 4-(1-Butyl-piperidin-4-yloxy)-3-methoxy-benzonitrile 

Relevant articles and documents

Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

The library of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors was designed and synthesized. H-Bond donors in piperidine ring were found to be important for reduced locomotor activity in mice. 4-[Bis(4-fluorophenyl)methoxy]piperidine has IC50 17.0 ± 1.0 nm for dopamine transporter and locomotor activity, which is lower than that for cocaine.

The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines

The synthesis of potent 4-aryl methoxypiperidinol inhibitors of the dopamine transporter is described. Symmetrical para substituents of the benzene rings are important for high potency in binding to the dopamine transporter. 4-[Bis(4-fluorophenyl) methoxy]-1-methylpiperidine has an IC50 of 22.1 ± 5.73 nM and increases locomotor activity in mice.