865362-74-9

Basic information

• Product Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
• Synonyms: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine;FR 180204;1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-;5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine FR 180204;5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine;LM-3319 FR 180204;ERK Inhibitor II, FR180204;FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK
• CAS NO: 865362-74-9
• Molecular Formula: C18H13N7
• Molecular Weight: 327
• Product Categories: Inhibitors
• Mol File: 865362-74-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 267 °C
• Appearance: faint yellow to dark yellow/
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: Store at +4°C
• Solubility: DMSO: ≥10mg/mL
• PKA: 7.19±0.50(Predicted)
• CAS DataBase Reference: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine(865362-74-9)
• EPA Substance Registry System: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine(865362-74-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-20
• Safety Statements: 20/21
• WGK Germany: 3
• Hazardous Substances Data: 865362-74-9(Hazardous Substances Data)

Usage

Description

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, also known as FR180204, is a compound that has been synthesized and studied for its potential as an ERK inhibitor. It is characterized by its unique molecular structure, which includes a pyrazolo[1,5-a]pyridine and a pyrazolo[3,4-c]pyridazine ring system, as well as a phenyl group attached to the former. 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine has been of interest in the field of cell biology and pharmacology due to its ability to modulate specific signaling pathways.

Uses

Used in Pharmaceutical Research:
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine is used as an ERK inhibitor for blocking extracellular-signal-regulated kinase (ERK) to validate the role of homeobox B7 (HOXB7) in the migration and proliferation process via the AKT/mitogen-activated protein kinases (MAPK) signaling pathway. This application is crucial for understanding the molecular mechanisms underlying various cellular processes and identifying potential therapeutic targets.
Used in Cell Biology Studies:
In cell biology research, 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine is used to study the effects of signaling pathway inhibitors on cell differentiation and cell traction stress. This helps researchers determine the importance of phosphorylation of ERK in these processes, which can provide insights into the development of new therapeutic strategies for various diseases.
Used in Mesenchymal Stromal Cell (MSC) Research:
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine is also used in mesenchymal stromal cell (MSC) research to investigate the essential role of ERK phosphorylation in MSC-derived therapeutic efficacy. This application is significant for advancing the understanding of MSC-based therapies and their potential use in regenerative medicine and tissue repair.

Biochem/physiol Actions

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

Upstream product

• 1196794-13-4 C₁₈H₁₀ClN₅ 

Relevant articles and documents

Multi-gram scale synthesis of FR180204

(Chemical Equation Presented) A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.