86541-77-7 Usage
Description
1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R,S)]-, also known as (1R,3S)-Benazepril Hydrochloride, is an isomer of Benazepril. It is a pharmaceutical compound belonging to the class of angiotensin-converting enzyme (ACE) inhibitors. 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R,S)]is characterized by its unique chemical structure, which includes a benzazepine ring and an acetic acid group, as well as an ethoxycarbonyl and phenylpropyl chain attached to an amino group. The presence of the hydrochloride salt form indicates that it is a salt derived from the reaction of the parent compound with hydrochloric acid. This modification enhances the solubility and stability of the compound, making it suitable for pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R,S)]is used as an angiotensin-converting enzyme (ACE) inhibitor for the treatment of hypertension. As an antihypertensive agent, it works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action results in the dilation of blood vessels, thereby reducing blood pressure and improving cardiovascular health.
Additionally, due to its ability to lower blood pressure, (1R,3S)-Benazepril Hydrochloride may also be used in the management of other cardiovascular conditions, such as heart failure and certain types of kidney diseases. Its use in these applications is based on its ability to reduce the workload on the heart and protect the kidneys from damage caused by high blood pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 86541-77-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,5,4 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86541-77:
(7*8)+(6*6)+(5*5)+(4*4)+(3*1)+(2*7)+(1*7)=157
157 % 10 = 7
So 86541-77-7 is a valid CAS Registry Number.
86541-77-7Relevant articles and documents
Chloramphenicol base chemistry. Part 10: Asymmetric synthesis of α-hydroxy chiral alcohols via intramolecular Michael additions of γ-hydroxy-α, β-unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts
Wang, Haifeng,Yan, Linjie,Wu, Yan,Chen, Fener
, p. 2793 - 2800 (2017/04/14)
We have developed the chloramphenicol base urea-catalyzed intramolecular Michael addition of γ-hydroxy-α, β-unsaturated enones. The oxidation of the resulting products provided facile access to the corresponding α-hydroxy chiral alcohols with good efficiency and enantioselectivity, with the reaction displaying broad substrate scope. The utility of this methodology was further demonstrated by the synthesis of (R)-2-hydroxy-4-phenylbutanoate, which is a key building block for the construction of the ACE inhibitor benazepril hydrochloride.
Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme
Watthey,Stanton,Desai,Babiarz,Finn
, p. 1511 - 1516 (2007/10/02)
Syntheses of the potent angiotensin converting enzyme inhibitor (3S)-1-(carboxymethyl)-3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5 -tetrahydro-1H-[1]benzazepin-2-one (CGS 14831) and the related monoester prodrug (17a; CGS 14824A) are described together with preparative details for six- and eight-membered ring analogues. Inhibitory potencies and in vivo biological activity of the compounds are discussed. The data indicate that 17a has a biological profile comparable to that of enalapril.
