86569-53-1

Basic information

• Product Name: 4'-chloro-2-methyl-2'-nitropropananilide
• Synonyms: 4'-chloro-2-methyl-2'-nitropropananilide
• CAS NO: 86569-53-1
• Molecular Weight: 242.662
• Mol File: 86569-53-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4'-chloro-2-methyl-2'-nitropropananilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-chloro-2-methyl-2'-nitropropananilide(86569-53-1)
• EPA Substance Registry System: 4'-chloro-2-methyl-2'-nitropropananilide(86569-53-1)

Safety Data

• Hazardous Substances Data: 86569-53-1(Hazardous Substances Data)

Upstream product

• 16883-61-7 trimethylsilyl isobutyrate 
• 89-63-4 4-Chloro-2-nitroaniline 

Downstream Products

• 86569-49-5 N-(2-Amino-4-chloro-phenyl)-isobutyramide 
• 86569-46-2 N-isobutyryl-N'-acetyl-4-chloro-1,2-phenylenediamine 
• 4886-29-7 5-chloro-2-(1-methylethyl)benzimidazole 

Relevant articles and documents

An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides

In the presence of a catalytic amount of active titanium(IV) salt generated in situ from 1 mol of TiCl4 and 2 mol of AgOTf, weakly nucleophilic anilines react under mild conditions with nearly equimolar amounts of silyl carboxylates to afford the corresponding anilides in excellent yields using 4-(trifluoromethyl)benzoic anhydride.The mixed anhydride formed in situ from trimethylsilyl acetate and 4-(trifluoromethyl)benzoic anhydride, a key intermediate of this reaction, was detected by 1H NMR experiment.Further, it was shown that the reaction of the mixed anhydrides and 2-nitroaniline was faster than that of the corresponding homo anhydrides and 2-nitroaniline.